Facilities & Equipment

RCC has a ‘state-of-the art’ pre-clinical research facility spreads over 55,000 sq. ft (5500 sq. m). The facility spreads over ground plus two floors engaging in breeding & testing, analytical chemistry, genetic toxicology, pathology, quality assurance, test item logistics and archives. Additionally, an independent building designed to accommodate ecotoxicology studies covering both aquatic (Algae, Daphnia, Fish, Lemna gibba), and terrestrial species (Bird, Earth worm, Honey bee, Silk worm and Insect predator).

• BD FACSVerse Flow Cytometer
• Advia 2120 Hematology System – Siemens
• Multi-mode micro plate reader
• Urine Analyzer –Roche
• Clinical Chemistry Analyzer –Roche
• Coagulation Analyzer –Roche
• Electrolyte Analyzer –Sensacore
• ELISA Microplate Reader
• ELISA Microplate Washer
• Automatic Tissue Processor
• Tissue Embedder (Embedding Station)
• Manual Microtome
• Fully Automated Microtome
• Inverted Microscope
• Trinocular Stereo microscope with camera
• CO₂ Incubator
• BOD Incubator
• Colony Counter
• Halogen Ophthalmoscope
• Opacitometer
• Luminometer
• Measurement of motor activity using IR motor activity monitor
• Grip strength meter –Ugobasile
• For neurobehavioral & memory testing: Water Maze, Plus maze, Radial Maze

• Preparatory HPLC
• High performance liquid chromatography (HPLC) with PDA/DAD, Refractive Index and Conductivity Detector.
• Gas chromatography–mass spectrometry (GC-MS)
• Gas chromatography (GC) with FID, FPD and ECD Detectors
• Fourier transform infrared (FTIR) spectroscopy
• UV/Visspectroscopy
• Stability Chamber (low & high temperature)
• Explosives and ignition test apparatus
• Transport Worthiness

RCC has Information Technology facility including WAN/LAN/Wi-Fi connectivity across the campus, effective multiple backup solution, data sharing, data and information security and disaster recovery measures. IT team supports validation of computerized systems and spread sheet validation in accordance with OECD GLP guidance number 17.

• CCTV surveillance throughout the premises
• WINGS Software
• Data is effectively stored, handled, protected and shared in a secured manner.
• Biometrics based attendance and access controlled facility
• User rights management to systems and devices
• Three-fold data backup solutions for all instruments
• Data Replication and Disaster recovery
• Various SOPs to manage operations
• Maintains e-copy of approved SOPs
• Monitoring environmental conditions through digital transfer
• Secure FTP server
• Tele-conference/Video-conference facility
• Universal Threat Management (UTM) appliances at the gateway level for Firewall, email system and Internet traffic monitoring

Independent Quality Assurance department to ensure all activities are in compliance with OECD Principles of Good Laboratory Practices (GLP).

• Periodical monitoring by Ms. Iris Wuethrich, QA Consultant, Switzerland
• Well established QA systems & procedures and trained auditors
• Continuous training program (internal & external)
• Conduct different types of audit as recommended by OECD guidance number 4

RCC has GLP compliant archives to ensure reliability, reproducibility and traceability of study specific records and material for a recommended period. The archives is environmentally controlled and maintained as required by OECD guidance number 15. RCC has controlled dedicated space for both paper as well as wet archives. For test item storage conditions include room temperature, desiccator, refrigerated and frozen at -20°C or -80°C. Validated electronic archival system is in place.

• Designed with full safety and fire proof systems
• Provided with Fire alarm/Smoke detector
• Retention of paper records using fire/water/acid resistant compactors
• Retention of wet tissues, paraffin blocks & stained slides
• Teratology specimen (rat and rabbit)
• Test item storage
• Electronic Archives
• Maintain chain of custody documents and disposal records

RCC has a separate Statistics department with experienced staff.

Statistical Program (STATPLUS Software Build 5.9.9.4/Core V6.7.3) is used for the data analysis pertaining to body weight, feed consumption, organ weights and clinical pathology data for long term toxicology studies including reproductive and carcinogenicity studies. For LD50 determination in ecotoxicology studies TOXSTAT version 3.5 statistical program is used

• Functions in compliance with OECD guidance number 19
• Independent and single point of receipt
• Advises required document(s) for customs requirement and facilitates for clearance
• Thorough physical verification of packaging material (container / bottle / aluminium pouch) on receipt
• Complete verification of documents viz., Certificate of Analysis (CoA), Test Item Data Sheet (TIDS), Safety Data Sheet etc.
• Acknowledging the receipt of test/reference/control item to the sponsor/client on time
• Aliquot of test/reference/control item to GLP archives as per guidance
• Assigning internal code for each sponsor to maintain confidentiality
• Equipped to store at different required temperature, stability to air and light
• Check for pH and solubility
• Handling and Dispensing under safety environment
• Maintain accountability from receipt to safe disposal