REACH Support



REACH (Registration, Evaluation and Authorization of Chemicals) is the EC1907/2006 Regulation, which is effective from 1stJune 2007 and replaces all previous legislation on authorization of chemicals in the European Union (EU). In fact, it opens a single window system, for both “existing” and “new” chemicals manufactured in or imported into the EU in quantities minimum 1 tonne or more per year. Although REACH is a European regulation, it impacts global manufacturers.

According to REACH requirements, industry has the responsibility to ensure that the chemicals it manufactures, imports and released in the EU market do not have adverse effect in both human health and/or the environment. It requires manufacturers and importers of chemicals into the European Union (EU) to submit hazard, use, and risk data for all compounds.

RCC has extensive knowledge and expertise to conduct studies as mentioned below for different tonnages. Also supports dossier preparation using the latest version of IUCLID tool for REACH support.

If any of your study requirements are not listed, please contact us.



Tonnage Physico-Chemical Properties Toxicology Ecotoxicology
1-10t State of the Substance at 200C and 101,3, kPa Skin corrosion(in vitro); Human Skin Model EPIDERM Short-term aquatic toxicity invertebrates (Daphnia)
Melting Point Skin irritation (in vitro)
Human Skin Model EPISKIN
Growth inhibition aquatic plants (algae)
Boiling Point Skin irritation (in vitro)
Human Skin Model EPIDERM
Ready biodegradability
Relative density (Liquids & Solids) Membrane Barrier Test (in vitro); Method of Skin Corrosion-CorrositexTM
Vapour pressure Eye irritation HET CAM
Surface Tension Eye Corrosion BCOP
Water Solubility (At one pH and one temperature) Eye Irritation (in vitro) Epi Ocular
Water Solubility (At pH 4, 7, 9 and in water at 200C; Temperature dependency at pH 7 (100C and 300C) Skin sensitization: Local Lymph Node Assay
Partition coefficient n-octanol/water Skin sensitization: Local Lymph Node Assay- BrdU-ELISA
Flash point (Liquids) Skin Sensitisation – Magnusson/Kligman
Flammability (Solids)
Explosive properties Reverse mutation Test (Ames-Test)
Self-ignition temperature (Liquids) Acute Oral Toxicity
Self-ignition temperature
Oxidising properties (Liquids)
Oxidising properties (Solids)
Granulometry (Solids)
10-100t Acute Skin irritation/corrosion(in vivo) Short-term aquatic toxicity in fish
Acute Eye irritation/corrosion (in vivo) Activated sludge respiration Inhibition test
Micronucleus Test in Chinese Hamster Cells (in vitro) Hydrolysis as a function of pH
Micronucleus Test in Human Lymphocytes (in vitro) Absorption/desorption screening
Chromosome Aberration Test in Chinese Hamster Cells (in vitro)
Chromosome Aberration Test in Human Lymphocytes
Mouse Lymphoma Assay
HPRT-Test
Acute toxicity (by inhalation)
Acute toxicity ( by dermal route)
Repeated Dose Oral Toxicity - 28 Day, Rat
Repeated Dose Dermal Toxicity - 21 Day, Rat
Repeated Dose Dermal Toxicity - 28 Day, Rat
Repeated Dose Inhalation Toxicity - 28 Day or 14 Day Study
Screening for reproductive/developmental toxicity -Rats
Combined repeated dose Toxicity study with the Reproductive/ Developmental Toxicity Screening Test-Rats
Toxicokinetics
100 -1000t Stability in organic solvents and identity of relevant degradation products Micronucleus Test-Mouse Peripheral Blood Cells (in vivo) Long-term aquatic toxicity on invertebrates (Daphnia) - 21 Day
Dissociation constant in water Micronucleus Test- Hematopoietic Bone Marrow (in vivo) Long-term aquatic toxicity in fish
Viscosity Chromosome Aberration-Test: Mouse
(in vivo)
Fish Early-Life Stage Toxicity test – Zebra fish
Unscheduled DNA Synthesis (UDS) test (in vivo) Short term toxicity test on Embryo and Sac-Fry stages for fish - Zebra fish
Comet assay (in vivo) Aerobic Transformation in 1 Soil (Route); Radiolabeled test item
Mammalian Spermatogonial Chromosome Aberration Test Aerobic Transformation in 1 Soil (Route); Radiolabeled test item
Repeated Dose Oral Toxicity - 90 Day; Rat Anaerobic Transformation in 1 Soil (Rate); per soil; depends strongly on set up; Radiolabeled test item
Repeated Dose Dermal Toxicity - 90 Day; Rat Aerobic Transformation in 2 Water/Sediment Systems; Radiolabeled test item
Sub-chronic Inhalation Toxicity - 90 Day Study Anaerobic Transformation in 2 Water/Sediment Systems; Radiolabeled test item
Pre-natal development toxicity study -Rat Aerobic mineralization in Surface Water
Pre-natal development toxicity study -Rabbit Identification of Metabolites (Degradation Products)
Bioaccumulation in aquatic species (fish)
Absorption/Desorption (5 soils); Tier 1-2 & Tier 1-3
Short-term terrestrial toxicity on invertebrates -Earthworm
Effects on soil micro-organisms
>1000t 52 week Oral Toxicity Study -Rats Terrestrial Plant Test: Seedling Emergence
Extended One Generation Reproductive Toxicity Study - Rat Terrestrial Plant Test: Vegetative Vigour
Two Generation Reproductive Toxicity Study - Rat Long -term terrestrial toxicity on invertebrates -Earthworm
2 Year Carcinogenicity Study in Rat Terrestrial Plant Test: Seedling Emergence
Dietary Combined Chronic Toxicity/Carcinogenicity Study in Wistar Rat Terrestrial Plant Test: Vegetative Vigour
Long term Toxicity to Sediment Organisms
Avian Reproduction Study